SEC Filings

8-K
PERNIX THERAPEUTICS HOLDINGS, INC. filed this Form 8-K on 02/19/2019
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18 Positioning / Messaging • Trusted hydrocodone, in a unique ER formulation, for a simple 1:1 conversion from IR hydrocodone • True 12 - hour dosing allows more consistent pain relief • Contains an indistinguishable mix of IR and CR hydrocodone beads, plus inert beads designed to provide abuse - deterrent properties • Unique formulation with 20% IR beads and 80% ER beads • Demonstrated pain control and tolerability with no pattern of end - of - dose failure (“EODF”) (1) • Proven to significantly reduce disability scores • No acetaminophen • Measurable levels within 30 minutes of first dose • Minimal peaks and troughs compared to IR hydrocodone • Zohydro ® ER with BeadTek ® dosing fits guidelines suggesting use of lower morphine milligram equivalents (MMEs) • No change in starting dose for patients with mild or moderate hepatic impairment, not contra - indicated for patients with severe hepatic impairment • Zohydro ® ER with BeadTek ® offers true 12 - hour pain relief (twice - a - day dosing) and includes abuse deterrent technology • Reduced risk of hepatic impairment when used chronically due to absence of acetaminophen in formulation • 1:1 conversion allows for easy and effective transition from IR hydrocodone to ER hydrocodone Start fast, finish strong Morning dose to evening dose (1) 11.6 Hours 12.3 Hours + 0.95 hours ranging from 8.4 to 14.6 (n=151) + 0.93 hours ranging from 9.5 to 15.4 (n=151) Zohydro ® ER with BeadTek ® is the Hydrocodone You Know in a Unique ER Formulation that Delivers True 12 - hour Pain Control from Start to Finish (1) Nalamachu S et al. Pain Medicine 2015; 16: 2338 - 2343 Zohydro ® ER with BeadTek ® Positioning